Larotrectinib Impurity 5(Larotrectinib DFP-PPPA Impurity)
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
CAS: 1223404-88-3
Molecular Formula: C16H15F2N5
Larotrectinib Impurity 5(Larotrectinib DFP-PPPA Impurity) - Names and Identifiers
Larotrectinib Impurity 5(Larotrectinib DFP-PPPA Impurity) - Physico-chemical Properties
| Molecular Formula | C16H15F2N5 |
| Molar Mass | 315.3206064 |
| Density | 1.50±0.1 g/cm3(Predicted) |
| pKa | 3.14±0.30(Predicted) |
| Storage Condition | 2-8℃ |
Larotrectinib Impurity 5(Larotrectinib DFP-PPPA Impurity) - Upstream Downstream Industry
| Downstream Products | LOXO-101 (sulfate) |
Larotrectinib Impurity 5(Larotrectinib DFP-PPPA Impurity) - Introduction
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine is (R)-5-(2-(2, 5-Difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine. The intermediate is an organic compound with the following properties:
Appearance: A white solid
Molecular formula: C, H, F, N
Molecular weight: 349.35g/mol
The (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine has the following uses:
1. Drug research and development: As an intermediate of LOXO101 (a pamex inhibitor), it is used to synthesize the drug.
Regarding the preparation method, the preparation of this intermediate is generally divided into a plurality of steps. First, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-L-yl) pyrrolidone was synthesized by a synthetic reaction, the reaction then reacts with 2-aminopyrrolo [1,5-a] pyrimidin-3-ol to produce the intermediate. Specific synthetic steps need to be designed according to specific chemical synthesis methods.
When using and handling (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine, you need to follow some safety information:
1. Wear personal protective equipment such as gloves and safety glasses when operating.
2. Avoid direct contact with skin, eyes and respiratory tract.
3. When used in a laboratory environment, operate under well-ventilated conditions.
4. When stored in the dark, dry, low temperature preservation.
Appearance: A white solid
Molecular formula: C, H, F, N
Molecular weight: 349.35g/mol
The (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine has the following uses:
1. Drug research and development: As an intermediate of LOXO101 (a pamex inhibitor), it is used to synthesize the drug.
Regarding the preparation method, the preparation of this intermediate is generally divided into a plurality of steps. First, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-L-yl) pyrrolidone was synthesized by a synthetic reaction, the reaction then reacts with 2-aminopyrrolo [1,5-a] pyrimidin-3-ol to produce the intermediate. Specific synthetic steps need to be designed according to specific chemical synthesis methods.
When using and handling (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine, you need to follow some safety information:
1. Wear personal protective equipment such as gloves and safety glasses when operating.
2. Avoid direct contact with skin, eyes and respiratory tract.
3. When used in a laboratory environment, operate under well-ventilated conditions.
4. When stored in the dark, dry, low temperature preservation.
Last Update：2024-04-09 21:49:45
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CAS: 1223404-88-3
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CAS: 1223404-88-3
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Product Name: (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine Visit Supplier Webpage Request for quotation
CAS: 1223404-88-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1223404-88-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Downstream Products for Larotrectinib Impurity 5(Larotrectinib DFP-PPPA Impurity)